Academy of Mathematics and Systems Science, CAS Colloquia & Seminars
Speaker:
Dr.Ruisheng Wang, Brigham and Women's Hospital, Harvard Medical School
Inviter:
王勇 副研究员
Title:
Network medicine approaches to deciphering placebo effects and repurposing drugs
Time & Venue:
2018.9.7 10:00 S705
Abstract:
The placebo effect is a phenomenon in which patients who are given an inactive treatment show a perceived or actual improvement in a medical condition. Placebo effects in clinical trials have been investigated for many years especially because placebo treatments often serve as the control arm of randomized clinical trial designs. Recent observations suggest that placebo effects may be modified by genetics. This observation has given rise to the term "placebome," which refers to a group of genome-related mediators that affect an individual's response to placebo treatments. In this talk, I will present a network analysis of the placebome which leads to identifying a placebome module in the human protein-protein interactome. To gain insights into placebo effects in different diseases and drug treatments, we use a network proximity measure to examine the closeness of the placebome module to different disease modules and drug target modules. I will also demonstrate how this network proximity approach can be used to repurpose existing drugs.