Speaker: 王曦廷

Title: Exploring the Shared Biomarkers between Cardioembolic Stroke and Atrial Fibrillation by WGCNA and Machine Learning

Language: Chinese

Time & Venue: 2024.12.10 20:00-20:40 思源楼425

Abstract: Cardioembolic Stroke (CS) and Atrial Fibrillation (AF) are prevalent diseases that significantly impact the quality of life and impose considerable financial burdens on society. Despite increasing evidence of a significant association between the two diseases, their complex interactions remain inadequately understood. In this report, we conducted bioinformatics analysis and employed machine learning techniques to investigate potential shared biomarkers between CS and AF. We retrieved the CS and AF datasets from the Gene Expression Omnibus (GEO) database and applied Weighted Gene Co-Expression Network Analysis (WGCNA) to develop co-expression networks aimed at identifying pivotal modules. We performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis on the shared genes within the modules related to CS and AF. The STRING database was used to build a protein-protein interaction (PPI) network, facilitating the discovery of hub genes within the network. Finally, several commonly used machine learning approaches were applied to construct the clinical predictive model of CS and AF. ROC curve analysis to evaluate the diagnostic value of the identified biomarkers for AF and CS. The results suggested that functional enrichment analysis indicated that pathways intrinsic to the immune response may be significantly involved in CS and AF.